PARIS, France, May 8, 2024, 8:30 a.m. CEST – Abivax SA (Euronext Paris & Nasdaq: ABVX) (“Abivax” or the “Company”), a clinical-stage biotechnology company focused on developing therapeutics that harness the body’s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases, today announced that four scientific abstracts on its lead drug candidate, obefazimod, for the treatment of moderately to severely active ulcerative colitis (UC) and in a preclinical model on colon cancer, will be presented at Digestive Disease Week (DDW) as part of scientific exchange, taking place May 18-21, 2024, in Washington D.C., U.S.
“With four abstracts accepted for presentation at DDW 2024, we look forward to our continued exchange with the IBD community around the emerging clinical profile of obefazimod,” said Sheldon Sloan, M.D., M. Bioethics, Chief Medical Officer of Abivax. “We are excited to share new preclinical data showing obefazimod’s impact in reducing the number of tumors in the azoxymethane (AOM)/dextran sodium sulfate (DSS) mouse model of colitis-associated cancer—data in support of obefazimod’s novel mechanism of action.”
For more information, visit the Abivax booth at the DDW exhibitor hall (booth #529) or see congress details on the DDW website.
Obefazimod data to be presented:
| Presentation Title | Session | Presenter | Presentation/ Session Number | Session Hall | Date and Time (EDT) | |
| Oral Presentation | ||||||
| Efficacy and safety of obefazimod in UC patients at weeks 48 and 96 of an open-label maintenance study among clinical responders at week 8 of the Phase 2b induction trial | IBD Controlled Trials II | Prof. Bruce E. Sands, M.D., M.S. Dr. Burrill B. Crohn Professor of Medicine and Chief, Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, NY |
May 21, 2024 8:00-9:30 a.m. |
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| Poster Presentations | ||||||
| Obefazimod and its active metabolites ABX-464-N-Glu act by stabilizing protein-protein interaction among key RNA biogenesis partners, CBC and ARS2 |
Cell and Molecular Biology of Gastrointestinal Disorders | Didier Scherrer, Ph.D. Chief Scientific Officer, Abivax |
May 18, 2024 12:30-1:30 p.m. |
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| Obefazimod reduces total number of tumors and high-grade adenomas in a murine colitis associated colorectal cancer model | GI Cancer Research Models: Organoids‚ Engineered Cell and Tissue Platforms‚ and Animal Models | Didier Scherrer, Ph.D. Chief Scientific Officer, Abivax |
May 18, 2024 12:30-1:30 p.m. |
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| Efficacy of once-daily, orally administered obefazimod in patients with moderately to severely active UC at weeks 8, 48, and 96 broken down by induction treatment dose | IBD: Controlled Clinical Trials in Humans | Prof. Bruce E. Sands, M.D., M.S. Dr. Burrill B. Crohn Professor of Medicine and Chief, Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, NY |
May 19, 2024 12:30-1:30 p.m. |
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Abivax has also sponsored a Product Theater presentation titled, “An Investigational New MOA that Can Stabilize the Inflammatory Response in Ulcerative Colitis,” taking place on May 20, 2024, at 2:30-3:15 p.m. EDT in room “DDW Theater 1,” featuring Prof. Parambir S. Dulai, M.D., Associate Professor of Medicine in the Division of Gastroenterology and Hepatology at Northwestern University, Evanston, Illinois, U.S.
About Obefazimod
Obefazimod, Abivax’s lead investigational drug candidate, is an orally administered small molecule that was demonstrated to potentially enhance the expression of a single microRNA, miR-124. Phase 2 clinical trials in patients with UC have generated positive data, resulting in the initiation of a pivotal global Phase 3 clinical trial program (ABTECT Program), with first patients enrolled in the United States in October 2022. Initiation of a Phase 2b clinical trial in Crohn’s disease is expected in Q3 2024, and exploration of potential combination therapy opportunities in UC is ongoing.
About Abivax
Abivax is a clinical-stage biotechnology company focused on developing therapeutics that harness the body’s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases. Based in France and the United States, Abivax’s lead drug candidate, obefazimod (ABX464), is in Phase 3 clinical trials for the treatment of moderately to severely active ulcerative colitis. More information on the Company is available at www.abivax.com. Follow us on LinkedIn and on X, formerly Twitter, @Abivax.
Contact:
Abivax Investor Relations
Patrick Malloy
patrick.malloy@abivax.com
+1 847 987 4878
Abivax Communications
communications@abivax.com
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